Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.75 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | F2R | P25116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800552 | 0.88 | P2RX1 (0.59) | RENP2RX1F2R | |
| SCHEMBL9225836 | 0.85 | REN (0.55) | RENP2RX1F2R | |
| SCHEMBL7326504 | 0.82 | REN (0.53) | REN | |
| SCHEMBL9554711 | 0.81 | REN (0.64) | RENP2RX1 | |
| SCHEMBL9554717 | 0.81 | REN (0.64) | RENP2RX1 | |
| SCHEMBL9800690 | 0.79 | REN (0.59) | RENP2RX1F2R | |
| SCHEMBL7335538 | 0.79 | REN (0.52) | REN | |
| SCHEMBL9800603 | 0.79 | REN (0.59) | RENP2RX1 | |
| SCHEMBL7329529 | 0.79 | REN (0.50) | REN | |
| SCHEMBL9800652 | 0.77 | P2RX1 (0.77) | RENP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634175-B1 | Pharmaceutical combination, containing a renin-angiotensin-system inhibitor and an endothelin antagonist | HOFFMANN LA ROCHE (CH) | 2001-01-10 | — | — | EP | disclosed |
| US-5696116-A | TREATING DISORDERS ASSOCIATED WITH VASOCONSTRICTION | HOFFMANN-LA ROCHE INC. (US) | 1997-12-09 | — | — | US | disclosed |