Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5690672 | 0.83 | HSP90AB1 (0.49) | HSP90AB1ALDH1A1GAAGFERPDGFRB | |
| SCHEMBL25368848 | 0.77 | LMNA (0.45) | ALDH1A1THRBMAPTLMNAHTT | |
| SCHEMBL2127228 | 0.76 | HSP90AB1 (0.63) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL8204330 | 0.76 | HSP90AB1 (0.68) | HSP90AB1ALDH1A1GAAGFERCYP4F2 | |
| SCHEMBL19224609 | 0.75 | PDGFRB (0.46) | HSP90AB1ALDH1A1GAAPDGFRBFGFR1 | |
| SCHEMBL1151448 | 0.75 | MTNR1A (0.43) | HSP90AB1ALDH1A1GAATHRBMAPT | |
| SCHEMBL4131823 | 0.75 | ATM (0.47) | HSP90AB1ALDH1A1GAAGFERPDGFRB | |
| SCHEMBL31463421 | 0.75 | POLB (0.56) | ALDH1A1GAAGFERCOMTMAPT | |
| SCHEMBL27176959 | 0.75 | POLB (0.56) | ALDH1A1GAAGFERCOMTMAPT | |
| SCHEMBL31458970 | 0.75 | HSP90AB1 (0.49) | HSP90AB1ALDH1A1GAAGFERPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133484-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca AB (SE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000005223-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-03 | — | — | WO | disclosed |