Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771680 | 0.91 | KDM4E (0.71) | ALDH1A1HPGDKDM4EHSD17B10BDKRB1 | |
| SCHEMBL6605329 | 0.89 | HTT (0.60) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL15635912 | 0.85 | KDM4E (0.62) | ALDH1A1HPGDKDM4EHSD17B10TLR8 | |
| SCHEMBL11492008 | 0.85 | KDM4E (0.54) | ALDH1A1HPGDKDM4EHSD17B10BDKRB1 | |
| SCHEMBL11604657 | 0.82 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EHSD17B10RIPK1 | |
| SCHEMBL27874325 | 0.81 | KDM4E (0.61) | ALDH1A1HPGDKDM4EHSD17B10TLR8 | |
| SCHEMBL9239004 | 0.81 | KDM4E (0.61) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL6612663 | 0.80 | ALDH1A1 (0.68) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL14155843 | 0.79 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4EHSD17B10RIPK1 | |
| SCHEMBL7737872 | 0.79 | KMT2A (0.49) | ALDH1A1HPGDKDM4EHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458636-B1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1995-07-12 | — | — | EP | disclosed |
| US-5248684-A | CERTAIN 2-OXO-QUINOLINE CARBOXYLATES OR CORRESPONDING CARBOXAMIDES USEFUL AS ANTI-EMETICS AND SUPPRESSANTS OF MIGRAINE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| EP-0458636-A1 | Antiemetic and migraine suppressing heterocyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1991-11-27 | — | — | EP | disclosed |