Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437816 | 0.91 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL6612663 | 0.88 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL11492008 | 0.88 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL8826118 | 0.84 | KDM4E (0.75) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL22731793 | 0.83 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL11607709 | 0.81 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL6605329 | 0.80 | HTT (0.60) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL9591599 | 0.79 | CNR2 (0.48) | KDM4EALDH1A1HPGDHSD17B10CNR2 | |
| SCHEMBL5871444 | 0.79 | PKM (0.58) | KDM4EALDH1A1HPGDRAB9ATDP1 | |
| SCHEMBL8692447 | 0.79 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1237888-B1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2006-09-13 | — | — | EP | disclosed |
| US-6852745-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-08 | — | — | US | disclosed |
| US-6835741-B2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-28 | — | — | US | disclosed |
| US-6638937-B2 | As antihypertensive agents; for therapy of disorders related to renal, glomerular and mesangial cell function; therapy of endotoxemia or endotoxin shock as well as hemorrhagic shock; useful in alleviation of pain associated cancer | BRISTOL-MYERS SQUIBB CO. | 2003-10-28 | — | — | US | disclosed |
| EP-1172109-A1 | COMPOSITIONS FOR PREVENTING AND TREATING TYPE I ALLERGY | Sunstar Inc. (JP) | 2002-01-16 | — | — | EP | disclosed |
| EP-1172443-A1 | METHOD FOR SCREENING CYSTEINE PROTEASE INHIBITOR | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-01-16 | — | — | EP | disclosed |