Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 20/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 16/20 | 0.59 |
| ▸ | F2 | P00734 | 11/20 | 0.59 |
| ▸ | F9 | P00740 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PROC | P04070 | 1/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019749 | 0.75 | F10 (1.00) | F10PRSS1F2F9PRSS2 | |
| SCHEMBL8032829 | 0.73 | F10 (1.00) | F10PRSS1F2F9PRSS2 | |
| SCHEMBL8029289 | 0.70 | F10 (1.00) | F10PRSS1F2PLGPROC | |
| SCHEMBL7473566 | 0.69 | F10 (1.00) | F10PRSS1F2F9PRSS2 | |
| SCHEMBL7019485 | 0.69 | F10 (0.54) | F10 | |
| SCHEMBL7438119 | 0.69 | F10 (0.66) | F10PRSS1F2F9PRSS2 | |
| SCHEMBL7367326 | 0.68 | F10 (1.00) | F10PRSS1F2F9PRSS2 | |
| SCHEMBL12132476 | 0.68 | F10 (0.75) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL7453073 | 0.67 | F10 (0.70) | F10PRSS1F2F9PRSS2 | |
| SCHEMBL7406525 | 0.67 | F10 (0.77) | F10PRSS1F2PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960102-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | Du Pont Pharmaceuticals Company (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998001428-A1 | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-01-15 | — | — | WO | claimed |