Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474135 | 1.00 | PDCD1LG2 (0.40) | PDCD1LG2CD274CA12CA2CA9 | |
| Hydrochloric Acid SCHEMBL2480213 | 0.85 | PDCD1LG2 (0.39) | PDCD1LG2CD274CA12CA2CA9 | |
| SCHEMBL2471466 | 0.84 | PTGS2 (0.38) | PDCD1LG2CD274CA12CA2CA9 | |
| SCHEMBL2474504 | 0.80 | ALOX5AP (0.38) | PDCD1LG2CD274MAPTTP53 | |
| SCHEMBL2480866 | 0.79 | HDAC4 (0.42) | PDCD1LG2CD274KDM4ESLC6A2SLC6A3 | |
| SCHEMBL2474346 | 0.79 | PDCD1LG2 (0.36) | PDCD1LG2CD274 | |
| SCHEMBL2476054 | 0.77 | FEN1 (0.40) | MEN1KMT2ACYP2C19LMNAMAPT | |
| SCHEMBL8995483 | 0.76 | ESR1 (0.41) | PDCD1LG2CD274CYP2C19ALDH1A1SLC6A2 | |
| SCHEMBL3105786 | 0.76 | PTPRC (0.37) | PDCD1LG2CD274CYP2C19 | |
| SCHEMBL2476954 | 0.76 | PDCD1LG2 (0.36) | PDCD1LG2CD274KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229381-A | Inhibitors of leukocyte enzyme elastase | MERCK & CO., INC. (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0481671-A1 | New substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |