Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.59 |
| ▸ | PDE4A | P27815 | 7/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.59 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438230 | 0.79 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5736549 | 0.77 | PDE4D (0.57) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5736544 | 0.77 | PDE4D (0.57) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5903060 | 0.76 | SLC6A3 (0.47) | — | |
| SCHEMBL7370960 | 0.76 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7370957 | 0.76 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5734935 | 0.76 | PDE4D (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7373715 | 0.75 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7367517 | 0.75 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7366496 | 0.75 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642489-A1 | CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993007111-A1 | CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-15 | — | — | WO | disclosed |