Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMKLR1 | Q99788 | 3/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 14/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 13/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436745 | 0.92 | AGTR1 (0.36) | AGTR1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL7438184 | 0.92 | CMKLR1 (0.37) | CMKLR1AGTR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7433092 | 0.92 | AGTR1 (0.34) | AGTR1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL7436500 | 0.91 | AGTR1 (0.34) | AGTR1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL7432327 | 0.89 | AGTR1 (0.36) | CMKLR1AGTR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7434203 | 0.89 | AGTR1 (0.36) | CMKLR1AGTR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7443465 | 0.87 | AGTR1 (0.41) | AGTR1AGTR2 | |
| SCHEMBL7444462 | 0.86 | AGTR1 (0.34) | CMKLR1AGTR1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7431258 | 0.86 | AGTR1 (0.42) | CMKLR1AGTR1AGTR2 | |
| SCHEMBL7443200 | 0.86 | AGTR1 (0.32) | CMKLR1AGTR1PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |