Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 10/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717337 | 0.85 | CTSK (0.52) | USP30CTSSCTSK | |
| SCHEMBL4711972 | 0.82 | CTSK (0.49) | USP30CTSSCTSKPIK3CDPIK3CA | |
| SCHEMBL4714872 | 0.81 | CTSS (0.43) | USP30CTSSCTSKPIK3CDPIK3CA | |
| SCHEMBL4715916 | 0.80 | CTSK (0.55) | USP30CTSSCTSK | |
| SCHEMBL4716533 | 0.78 | CTSK (0.52) | USP30CTSSCTSKPRMT5WDR77 | |
| SCHEMBL7504106 | 0.75 | USP30 (0.43) | USP30CTSSCTSKPIK3CDPIK3CA | |
| SCHEMBL4717334 | 0.74 | CTSK (0.70) | CTSSCTSK | |
| SCHEMBL4711970 | 0.72 | CTSK (0.67) | CTSSCTSK | |
| SCHEMBL4714869 | 0.71 | CTSK (0.59) | CTSSCTSK | |
| SCHEMBL6217327 | 0.70 | CTSK (0.46) | CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001049288-A9 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2001-10-25 | — | — | WO | disclosed |