Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 15/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.60 |
| ▸ | PDE4A | P27815 | 2/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7395148 | 0.76 | PDE3A (0.63) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Imazodan SCHEMBL148436 | 0.75 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Imazodan SCHEMBL124243 | 0.74 | PDE3B (0.97) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10468427 | 0.73 | PDE3B (0.69) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10648314 | 0.72 | PDE3B (0.60) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7278112 | 0.71 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10381776 | 0.71 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7436364 | 0.70 | EGLN2 (0.35) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11228219 | 0.69 | KCNH2 (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10648101 | 0.68 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243483-A4 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | — | 1990-10-10 | — | — | EP | claimed |
| EP-0243483-A1 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1987-11-04 | — | — | EP | claimed |
| WO-1987002587-A1 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1987-05-07 | — | — | WO | claimed |