Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 16/20 | 0.63 |
| ▸ | PDE3B | Q13370 | 14/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.63 |
| ▸ | PDE4A | P27815 | 3/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.63 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10554354 | 0.78 | PDE3A (0.61) | PDE3APDE3BPDE4BPDE4APDE4C | |
| Ci-930 SCHEMBL6052113 | 0.77 | PDE3B (1.00) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10553122 | 0.76 | PDE3B (0.69) | PDE3APDE3BPDE4BPDE4APDE4C | |
| Ci-930 SCHEMBL10657390 | 0.76 | PDE3B (0.98) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10469492 | 0.76 | PDE3B (0.71) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL7438685 | 0.76 | PDE3B (0.60) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10646114 | 0.74 | PDE3A (0.63) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10549976 | 0.74 | PDE3B (0.68) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10551547 | 0.74 | PDE3A (0.61) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10383108 | 0.73 | PDE3B (0.64) | PDE3APDE3BPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0243483-A4 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | — | 1990-10-10 | — | — | EP | claimed |
| EP-0243483-A1 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1987-11-04 | — | — | EP | claimed |
| WO-1987002587-A1 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1987-05-07 | — | — | WO | claimed |
| EP-0243483-A4 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | — | 1990-10-10 | — | — | EP | disclosed |
| EP-0243483-A1 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1987-11-04 | — | — | EP | disclosed |
| WO-1987002587-A1 | PYRIDYL-PYRIDAZONE AND PYRIDYL-PYRAZOLINONE CARDIOTONICS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1987-05-07 | — | — | WO | disclosed |