Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29013938 | 0.70 | DDB1 (0.52) | DDB1CRBNMAOBHDAC8KMT2A | |
| SCHEMBL837901 | 0.69 | DDB1 (0.60) | DDB1CRBNMAOBHDAC8KMT2A | |
| SCHEMBL6565739 | 0.69 | DDB1 (0.51) | DDB1CRBNMAOBCA2HDAC8 | |
| SCHEMBL7268381 | 0.69 | CRBN (0.70) | DDB1CRBNMAOBCA2HDAC8 | |
| SCHEMBL7566142 | 0.68 | MAOB (0.51) | DDB1CRBNMAOBCA2HDAC8 | |
| SCHEMBL28650432 | 0.67 | DDB1 (0.49) | DDB1CRBNMAOBCA2HDAC8 | |
| SCHEMBL8521910 | 0.67 | CRBN (1.00) | DDB1CRBNHDAC8KMT2A | |
| SCHEMBL6829791 | 0.67 | CRBN (0.57) | DDB1CRBNMAOBCA2HDAC8 | |
| SCHEMBL7441792 | 0.67 | DDB1 (0.49) | DDB1CRBNMAOBCA2HDAC8 | |
| SCHEMBL22559966 | 0.67 | DDB1 (0.49) | DDB1CRBNMAOBCA2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739338-A4 | NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE | UNIV WICHITA STATE (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0739338-A1 | NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE | THE WICHITA STATE UNIVERSITY (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018797-A1 | NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE | THE WICHITA STATE UNIVERSITY (US) | 1995-07-13 | — | — | WO | disclosed |