Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 4/20 | 0.39 |
| ▸ | CASP1 | P29466 | 3/20 | 0.39 |
| ▸ | CASP7 | P55210 | 3/20 | 0.39 |
| ▸ | CASP6 | P55212 | 3/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438981 | 1.00 | POLB (0.40) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7431367 | 0.94 | HPGD (0.42) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7306949 | 0.94 | HPGD (0.42) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7314551 | 0.92 | KMT2A (0.40) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7314563 | 0.92 | KMT2A (0.40) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7302479 | 0.92 | ALDH1A1 (0.48) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7302463 | 0.92 | ALDH1A1 (0.48) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7439506 | 0.92 | USP2 (0.39) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7311889 | 0.92 | USP2 (0.39) | POLBHPGDUSP2ALDH1A1MAPT | |
| SCHEMBL7438985 | 0.89 | ALDH1A1 (0.40) | POLBHPGDUSP2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |