Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18171802 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNARAB9AKDM4EMAPK1 | |
| SCHEMBL12611486 | 0.78 | GLA (0.62) | SMN1; SMN2LMNARAB9AKDM4EMAPK1 | |
| SCHEMBL18171828 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAKDM4EMAPTKMT2A | |
| SCHEMBL7482859 | 0.74 | RAB9A (0.46) | SMN1; SMN2LMNARAB9AKDM4EMAPT | |
| SCHEMBL7199062 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAMAPTKMT2AMEN1 | |
| SCHEMBL7814763 | 0.73 | HDAC1 (0.51) | SMN1; SMN2MAPTMAPK1TP53 | |
| SCHEMBL11999986 | 0.70 | KDM4E (0.67) | SMN1; SMN2LMNARAB9AKDM4EMAPT | |
| SCHEMBL5320439 | 0.70 | ALDH1A1 (0.58) | SMN1; SMN2LMNAMAPK1KMT2AMEN1 | |
| SCHEMBL5324208 | 0.70 | ALDH1A1 (0.67) | SMN1; SMN2LMNAKDM4EMAPK1KMT2A | |
| SCHEMBL11999961 | 0.70 | KDM4E (0.74) | RAB9AKDM4EMAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575503-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1986-03-11 | — | — | US | disclosed |
| US-4473575-A | ANGIOTENSIN INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-09-25 | — | — | US | disclosed |
| US-4410520-A | ANGIOTENSION CONVERTING ENZYME INGIBITOR, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0072352-A1 | Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use | CIBA-GEIGY AG (CH) | 1983-02-16 | — | — | EP | disclosed |