Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SHBG | P04278 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19861706 | 1.00 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKPTGS2 | |
| SCHEMBL7459485 | 1.00 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKPTGS2 | |
| SCHEMBL19441219 | 1.00 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKPTGS2 | |
| SCHEMBL18531931 | 1.00 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKPTGS2 | |
| Hydrochloric Acid SCHEMBL6462303 | 0.98 | KCNH2 (0.46) | KCNH2ALDH1A1TSHRCTSKPTGS2 | |
| SCHEMBL4077786 | 0.98 | KCNH2 (0.44) | KCNH2ALDH1A1TSHRCTSKPTGS2 | |
| SCHEMBL14973055 | 0.96 | KCNH2 (0.44) | KCNH2ALDH1A1TSHRCTSKPTGS2 | |
| Fluoride SCHEMBL27856901 | 0.96 | KCNH2 (0.42) | KCNH2ALDH1A1TSHRCTSKPTGS2 | |
| SCHEMBL1527338 | 0.92 | — | — | |
| Pyridine SCHEMBL27766962 | 0.86 | TDP1 (0.40) | KCNH2SLC6A3KDM4ELMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190241550-A1 | HETEROCYCLIC SUBSTITUTED-3-HETEROARYLIDENYL-2-INDOLINONE DERIVATIVE | BOSTON BIOMEDICAL INC (US) | 2019-08-08 | — | — | US | disclosed |
| US-20190048020-A1 | DEUTERIUM-MODIFIED CFTR MODULATORS | CONCERT PHARMACEUTICALS, INC. | 2019-02-14 | — | — | US | disclosed |
| US-9891239-B2 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| EP-0492930-A2 | Transdermal delivery of dobutamine | ELI LILLY AND COMPANY (US) | 1992-07-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048020-A1 | DEUTERIUM-MODIFIED CFTR MODULATORS | CFTR, PKD2, PKD1 | KCNH2 173/4885ALDH1A1 3553/4885TSHR 886/4885 |
| US-20190241550-A1 | HETEROCYCLIC SUBSTITUTED-3-HETEROARYLIDENYL-2-INDOLINONE DERIVATIVE | CYP2C9, DHRS9, HTR3B | KCNH2 196/4885ALDH1A1 385/4885TSHR 548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.