Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459485 | 0.98 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKSLC6A3 | |
| SCHEMBL19441219 | 0.98 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKSLC6A3 | |
| SCHEMBL7439199 | 0.98 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKSLC6A3 | |
| SCHEMBL19861706 | 0.98 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKSLC6A3 | |
| SCHEMBL18531931 | 0.98 | KCNH2 (0.47) | KCNH2ALDH1A1TSHRCTSKSLC6A3 | |
| Fluoride SCHEMBL27856901 | 0.98 | KCNH2 (0.42) | KCNH2ALDH1A1TSHRCTSKSLC6A3 | |
| Hydrochloric Acid SCHEMBL6462303 | 0.96 | KCNH2 (0.46) | KCNH2ALDH1A1TSHRCTSKSLC6A3 | |
| SCHEMBL14973055 | 0.94 | KCNH2 (0.44) | KCNH2ALDH1A1TSHRCTSKSLC6A3 | |
| SCHEMBL1527338 | 0.94 | — | — | |
| Pyridine SCHEMBL27766962 | 0.88 | TDP1 (0.40) | KCNH2SLC6A3LMNATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009041790-A1 | NOVEL 2,4,5-TRISUBTITUTED-1,3-THIAZOLE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 2,4,5- TRISUBSTITUTED-1,3-THIAZOLE DERIVATIVES AS AN EFFECTIVE INGREDIENT | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2009-04-02 | — | — | WO | claimed |
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | claimed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | claimed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | claimed |
| JP-5097816-A | — | — | None | — | — | JP | disclosed |
| WO-2024105635-A1 | USES OF ZLN-005 AND RELATED COMPOUNDS | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE (JP) | 2024-05-23 | — | — | WO | disclosed |
| US-20230286933-A1 | 2,5-ARYL-THIAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SOUTHERN RES INST (US) | 2023-09-14 | — | — | US | disclosed |
| US-11718593-B2 | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases | SOUTHERN RESEARCH INSTITUTE (US) | 2023-08-08 | — | — | US | disclosed |
| CN-109810073-B | 4-arylthiazole derivatives and pharmaceutical compositions thereof | 南京海辰药业股份有限公司 | 2023-01-06 | — | — | CN | disclosed |
| US-20210246110-A1 | 2,5-ARYL-THIAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SOUTHERN RESEARCH INSTITUTE | 2021-08-12 | — | — | US | disclosed |
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| US-20140235863-A1 | SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-08-21 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| JP-H0597816-A | 4-ARYL-THIAZOLE OR IMIDAZOLE DERIVATIVE | AKZO NV | 1993-04-20 | — | — | JP | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |
| US-4225666-A | Silver halide precipitation and methine dye spectral sensitization process and products thereof | EASTMAN KODAK COMPANY (US) | 1980-09-30 | — | — | US | disclosed |
| US-4183756-A | PRECIPITATION OF WILVER HALIDE PARTICLES IN PRESENCE OF METHINE DYE | EASTMAN KODAK COMPANY (US) | 1980-01-15 | — | — | US | disclosed |
| US-RE29843-E | Substituted thiazoles and flavoring processes and products produced thereby | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1978-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718593-B2 | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases | SMN1; SMN2, TDP2, TDP1 | KCNH2 4715/4885ALDH1A1 1090/4885TSHR 2933/4885 |
| US-20140235863-A1 | SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF | TST, NQO1, FNTB | KCNH2 3626/4885ALDH1A1 111/4885TSHR 1120/4885 |
| US-20210246110-A1 | 2,5-ARYL-THIAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SMN1; SMN2, TDP2, TDP1 | KCNH2 4715/4885ALDH1A1 1090/4885TSHR 2933/4885 |
| US-20230286933-A1 | 2,5-ARYL-THIAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SMN1; SMN2, TDP2, TDP1 | KCNH2 4715/4885ALDH1A1 1090/4885TSHR 2933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.