DHRS9

Dehydrogenase/reductase SDR family member 9 · Q9BPW9 · DHRS9 on Sugi Atlas →

2,173 patent compounds predicted against DHRS9, 1,914 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Indomethacin (SCHEMBL9300)	1.00	1/20
Indomethacin (SCHEMBL3518614)	1.00	1/20
Indomethacin (SCHEMBL42049)	0.98	1/20
Indomethacin (SCHEMBL43583)	0.98	1/20
Indomethacin (SCHEMBL473598)	0.98	1/20
Indomethacin (SCHEMBL1394949)	0.98	1/20
Indomethacin (SCHEMBL1817813)	0.98	1/20
Indomethacin (SCHEMBL3860125)	0.98	1/20
Indomethacin (SCHEMBL4880273)	0.98	1/20
Indomethacin (SCHEMBL41305)	0.96	1/20
Indomethacin (SCHEMBL5075022)	0.88	1/20
Indomethacin (SCHEMBL2230394)	0.86	1/20
Acemetacin (SCHEMBL5306430)	0.85	1/20
SCHEMBL3813031	0.84	1/20
SCHEMBL5534201	0.84	1/20
Indomethacin (SCHEMBL2280709)	0.83	1/20
SCHEMBL2600801	0.83	1/20
SCHEMBL2238173	0.82	1/20
SCHEMBL1082631	0.81	1/20
Acemetacin (SCHEMBL23843)	0.81	1/20

Clinical trials — most relevant to DHRS9 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)	PHASE4	UNKNOWN
Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum	PHASE3	COMPLETED
Androgen Ablation Therapy With or Without Chemotherapy in Treating Patients With Metastatic Prostate Cancer	PHASE3	COMPLETED
Targeting de Novo Pyrimidine Biosynthesis by Leflunomide for the Treatment of COVID-19 Virus Disease	PHASE3	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Capecitabine as Second-Line Therapy in Treating Patients With Stage IV Pancreatic Cancer Who Have the Thymidylate Synthase Gene	PHASE2	COMPLETED
Vitamin D Intervention Trial in Healthy Chinese, Phase II	PHASE1	COMPLETED
A Phase 1 Clinical Trial DHP2306R1 and DHP2306R2 in Healthy Adult Volunteers	PHASE1	COMPLETED
SPK Study in Afghanistan	nan	COMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
Precision Medicine in the Prostate Cancer Care Pathway	nan	RECRUITING
5-Alpha Reductase 2 as a Marker of Resistance to 5ARI Therapy	nan	RECRUITING
Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis	nan	RECRUITING
Mutation Analysis of 17βhydroxysteroid Dehydrogenase 3 Deficiency	nan	UNKNOWN
Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)	nan	COMPLETED
Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii	nan	ACTIVE_NOT_RECRUITING
Mechanistic Studies of Teriflunomide in RRMS	nan	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Pharmacogenetic Determinants Of Treatment Response In Children	nan	RECRUITING
Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines.	nan	COMPLETED
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
A Long-Term Study of Cholesterol Supplements for Smith-Lemli-Opitz Syndrome	nan	WITHDRAWN
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas	nan	UNKNOWN
Characterizing a 5P-Linked BHR Susceptibility Locus	nan	COMPLETED
Genetic Analysis of Hereditary Non-Syndromic Oral Clefts	nan	COMPLETED
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder	nan	UNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Involvement of Pollutants in Atopic Dermatitis and Psoriasis	nan	UNKNOWN
Molecular Epidemiology of Parkinson's Disease	nan	COMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DHRS9 binder may also engage these)

Protein	Name	Similarity
Q58NB6	—	1.000	Q58NB6 →
Q8HYR6	—	1.000	Q8HYR6 →
Q8K3P0	—	1.000	Q8K3P0 →
Q8VD48	—	0.999	Q8VD48 →
Q8NEX9	—	0.997	Q8NEX9 →
A4IFM3	—	0.992	A4IFM3 →
Q8N3Y7	—	0.990	Q8N3Y7 →
Q9M2E2	—	0.985	Q9M2E2 →
P29147	—	0.984	P29147 →
Q80XN0	—	0.984	Q80XN0 →
Q9ZUH5	—	0.983	Q9ZUH5 →
Q05A13	—	0.983	Q05A13 →
O54753	—	0.982	O54753 →
A7LB60	—	0.982	A7LB60 →
Q8TC12	—	0.982	Q8TC12 →
Q02338	—	0.981	Q02338 →
P0DKC6	—	0.981	P0DKC6 →
P0DKC5	—	0.981	P0DKC5 →
Q4JK73	—	0.981	Q4JK73 →
Q9R092	—	0.981	Q9R092 →
Q7TQA3	—	0.980	Q7TQA3 →
Q5NVG2	—	0.980	Q5NVG2 →
Q80ZF7	—	0.980	Q80ZF7 →
A5PJF6	—	0.980	A5PJF6 →
Q9QYF1	—	0.980	Q9QYF1 →
Q8CEE7	—	0.979	Q8CEE7 →
Q7T2D1	—	0.979	Q7T2D1 →
HSD17B13	17-beta-hydroxysteroid dehydrogenase 13	0.979	landscape →
Q6QA33	—	0.979	Q6QA33 →
Q02337	—	0.979	Q02337 →