Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8806406 | 0.84 | HDAC4 (0.46) | HDAC4HDAC8ALDH1A1MCL1ACHE | |
| SCHEMBL1714263 | 0.80 | HDAC4 (0.43) | HDAC4HDAC8ALDH1A1TACR1MCL1 | |
| SCHEMBL11951565 | 0.78 | TAAR1 (0.49) | HDAC4HDAC8ALDH1A1ACHEBCHE | |
| SCHEMBL4174582 | 0.77 | RNASEH1 (0.47) | HDAC4HDAC8ALDH1A1MCL1SMN1; SMN2 | |
| SCHEMBL7921522 | 0.75 | KMT2A (0.56) | ALDH1A1TACR1MEN1KMT2ATSHR | |
| SCHEMBL9156350 | 0.75 | HDAC4 (0.50) | HDAC4HDAC8ALDH1A1ACHEBCHE | |
| SCHEMBL19123039 | 0.73 | HDAC4 (0.43) | HDAC4HDAC8TSHR | |
| SCHEMBL17540837 | 0.73 | NFKB1 (0.44) | HDAC4HDAC8TSHR | |
| SCHEMBL21449130 | 0.73 | HDAC4 (0.43) | HDAC4HDAC8TSHR | |
| SCHEMBL12923997 | 0.73 | PDCD1 (0.47) | HDAC4HDAC8TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703071-A | Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0546102-B1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | UPJOHN CO (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5594144-A | TREATING CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1992004338-A1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | THE UPJOHN COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |