SCHEMBL7439402

SCHEMBL7439402

O=CC1CCc2ccccc2C(=O)N1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.47
PARP1 P09874 3/20 0.47
PDPK1 O15530 1/20 0.47
PARP10 Q53GL7 1/20 0.47
PARP11 Q9NR21 1/20 0.47
CYP19A1 P11511 3/20 0.42
CA12 O43570 1/20 0.42
CA9 Q16790 1/20 0.42
CES1 P23141 1/20 0.41
TDP2 O95551 1/20 0.40
CASP3 P42574 1/20 0.40
CASP7 P55210 1/20 0.40
CASP9 P55211 1/20 0.40
CASP6 P55212 1/20 0.40
CASP8 Q14790 1/20 0.40
MAP3K14 Q99558 1/20 0.40
MAOA P21397 2/20 0.38
CYP2A6 P11509 1/20 0.38
MAOB P27338 1/20 0.38
KDM4E B2RXH2 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22799843 0.88 CYP2A6 (0.45) TSHRPARP1PDPK1PARP10PARP11
SCHEMBL22799721 0.88 CYP2A6 (0.45) TSHRPARP1PDPK1PARP10PARP11
SCHEMBL22799901 0.88 CYP2A6 (0.45) TSHRPARP1PDPK1PARP10PARP11
SCHEMBL9732504 0.83 TSHR (0.59) TSHRPARP1PDPK1PARP10PARP11
SCHEMBL1550271 0.77 MTNR1A (0.42) HTR2AMAPT
SCHEMBL30929595 0.77 MTNR1A (0.42) HTR2AMAPT
SCHEMBL22799733 0.76 TSHR (0.38) TSHRPARP1PDPK1PARP10PARP11
SCHEMBL22799735 0.76 TSHR (0.38) TSHRPARP1PDPK1PARP10PARP11
SCHEMBL22800228 0.76 CYP2A6 (0.40) TSHRPARP1PDPK1PARP10PARP11
SCHEMBL22799585 0.76 CYP2A6 (0.40) TSHRPARP1PDPK1PARP10PARP11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0462884-B1 TRH DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ADIR ET COMPAGNIE (FR) 1993-06-16 EP disclosed
US-5190923-A For treatment of neurological disorders such as cognitive disorders ADIR ET COMPAGNIE (FR) 1993-03-02 US disclosed
EP-0462884-A1 TRH derivatives, their preparations and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1991-12-27 EP disclosed