Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 3/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1950426 | 0.80 | ADRA1A (0.51) | HSD11B1DRD2ADRA1AKDM4EALDH1A1 | |
| SCHEMBL1950428 | 0.80 | ADRA1A (0.51) | HSD11B1DRD2ADRA1AKDM4EALDH1A1 | |
| SCHEMBL15139456 | 0.80 | ADRA1A (0.51) | HSD11B1DRD2ADRA1AKDM4EALDH1A1 | |
| SCHEMBL9964006 | 0.80 | ADRA1A (0.51) | HSD11B1DRD2ADRA1AKDM4EALDH1A1 | |
| SCHEMBL1870138 | 0.79 | HSD11B1 (1.00) | HSD11B1DRD2ADRA1A | |
| SCHEMBL1871835 | 0.79 | HSD11B1 (1.00) | HSD11B1DRD2ADRA1A | |
| SCHEMBL15139395 | 0.79 | HSD11B1 (1.00) | HSD11B1DRD2ADRA1A | |
| SCHEMBL9964002 | 0.79 | HSD11B1 (1.00) | HSD11B1DRD2ADRA1A | |
| SCHEMBL1868061 | 0.79 | HSD11B1 (1.00) | HSD11B1DRD2ADRA1A | |
| SCHEMBL1870135 | 0.79 | HSD11B1 (1.00) | HSD11B1DRD2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |