Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437678 | 0.94 | ITK (0.38) | ITKCCR3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7440653 | 0.78 | TDP1 (0.32) | GCKCCR3NPC1SMN1; SMN2LMNA | |
| SCHEMBL4034477 | 0.77 | KDM4E (0.42) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL21438696 | 0.75 | KDM4E (0.41) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL1060220 | 0.75 | CCR1 (0.42) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7440660 | 0.75 | SMN1; SMN2 (0.33) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL9129273 | 0.75 | PDE4A (0.52) | LMNAKDM4EMEN1KMT2AHTT | |
| SCHEMBL7441262 | 0.75 | CCR3 (0.44) | ITKCCR3CCR1CCR8CCNB2 | |
| SCHEMBL7443607 | 0.75 | PDE4A (0.53) | ITKCCR3 | |
| SCHEMBL7441197 | 0.74 | KDM4E (0.51) | NPC1RAB9ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |