Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892623 | 1.00 | KLK5 (0.48) | KLK5CTSSCTSKRENCTSD | |
| SCHEMBL7435516 | 0.89 | KLK5 (0.60) | KLK5CTSSCTSKRENCTSD | |
| SCHEMBL7638374 | 0.89 | KLK5 (0.60) | KLK5CTSSCTSKRENCTSD | |
| SCHEMBL7638333 | 0.83 | PTPN1 (0.52) | KLK5RENCTSDPSEN1PSEN2 | |
| SCHEMBL7638338 | 0.83 | PTPN1 (0.52) | KLK5RENCTSDPSEN1PSEN2 | |
| SCHEMBL1401046 | 0.83 | CTSK (0.46) | CTSSCTSKTSHRPTPRB | |
| SCHEMBL1401049 | 0.83 | CTSK (0.46) | CTSSCTSKTSHRPTPRB | |
| SCHEMBL28034674 | 0.81 | CTSS (0.54) | KLK5CTSSCTSKPSEN1PSEN2 | |
| SCHEMBL8265825 | 0.78 | KLK5 (0.52) | KLK5CTSD | |
| SCHEMBL8266498 | 0.78 | KLK5 (0.52) | KLK5CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643878-A | TREATMENT OF RETROVIRAL DISEASES LIKE AIDS | CIBA-GEIGY CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| WO-1996016980-A1 | MORPHOLINOETHYLAMIDE DERIVATIVES | NOVARTIS AG (CH) | 1996-06-06 | — | — | WO | disclosed |
| EP-0532466-A2 | Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use | CIBA-GEIGY AG (CH) | 1993-03-17 | — | — | EP | disclosed |