Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.89 |
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.74 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.74 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.74 |
| ▸ | AHR | P35869 | 1/20 | 0.59 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.59 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2138422 | 0.98 | MAPT (0.92) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL518954 | 0.94 | MAPT (1.00) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL21120273 | 0.89 | MAPT (0.89) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL23766313 | 0.86 | MAPT (0.67) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| Sulfuric Acid SCHEMBL6194221 | 0.85 | MAPT (0.83) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| Oxalic Acid SCHEMBL8173155 | 0.85 | MAPT (0.83) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL4227502 | 0.85 | NPC1 (1.00) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL10032 | 0.85 | NPC1 (1.00) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL29365738 | 0.85 | NPC1 (1.00) | MAPTNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL22044245 | 0.85 | MAPT (0.63) | MAPTNPC1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0119161-B1 | BENZAZOCINONE AND BENZAZONINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS, AND THEIR THERAPEUTICAL USE | CIBA-GEIGY AG (CH) | 1989-06-28 | — | — | EP | disclosed |
| US-4537885-A | SUBSTITUTED 1-CARBOXY-3-(CARBOXYMETHYLAMINO)-2-ONE DERIVATIVES, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | CIBA GEIGY CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0126401-A1 | Indole compounds | CIBA-GEIGY AG (CH) | 1984-11-28 | — | — | EP | disclosed |
| EP-0119161-A2 | Benzazocinone and benzazoninone derivatives, process for their preparation, pharmaceutical preparations containing these compounds, and their therapeutical use | CIBA-GEIGY AG (CH) | 1984-09-19 | — | — | EP | disclosed |
| US-4470988-A | HYPOTENSIVE AGENTS, ENZYME INHIBITOR, CARDIAC DISORDERS | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |