Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731518 | 0.83 | ALDH1A1 (0.39) | ALDH1A1MAPK1 | |
| SCHEMBL14150097 | 0.79 | ALDH1A1 (0.39) | ALDH1A1MAPK1 | |
| SCHEMBL308369 | 0.78 | CA12 (0.48) | ALDH1A1MAPK1 | |
| SCHEMBL308949 | 0.76 | HSD17B2 (0.48) | ALDH1A1MAPK1 | |
| SCHEMBL308549 | 0.76 | GLA (0.41) | ALDH1A1MAPK1 | |
| SCHEMBL308824 | 0.74 | ALDH1A1 (0.38) | ALDH1A1MAPK1 | |
| SCHEMBL731441 | 0.74 | MAPT (0.40) | ALDH1A1MAPK1 | |
| SCHEMBL309993 | 0.72 | TSHR (0.38) | ALDH1A1MAPK1 | |
| SCHEMBL731446 | 0.69 | SMN1; SMN2 (0.37) | ALDH1A1MAPK1 | |
| SCHEMBL22530121 | 0.67 | XDH (0.60) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | AGTR1 13/4885AGTR2 24/4885ALDH1A1 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.