Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARN | O95453 | 1/20 | 0.39 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438053 | 0.83 | MAPT (0.41) | GAASMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL7434632 | 0.82 | GAA (0.48) | GAASMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL7445594 | 0.81 | SMN1; SMN2 (0.62) | GAASMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL7443156 | 0.79 | SMN1; SMN2 (0.54) | GAASMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL7443243 | 0.77 | HIF1A (0.53) | GAASMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL13789751 | 0.76 | MAPT (0.69) | SMN1; SMN2ALDH1A1HIF1ATSHRTP53 | |
| SCHEMBL7441118 | 0.75 | GAA (0.47) | GAASMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL7438604 | 0.75 | GAA (0.47) | GAASMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL7441123 | 0.75 | GAA (0.47) | GAASMN1; SMN2ADORA2BRXFP1ALDH1A1 | |
| SCHEMBL7438608 | 0.75 | GAA (0.47) | GAASMN1; SMN2ADORA2BRXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |