Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445594 | 0.94 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1GAAPCSK9ADORA2B | |
| SCHEMBL7443243 | 0.81 | HIF1A (0.53) | SMN1; SMN2ALDH1A1GAAADORA2BRXFP1 | |
| SCHEMBL18990814 | 0.79 | MAPT (0.52) | SMN1; SMN2LMNATP53MAPTTSHR | |
| SCHEMBL7440073 | 0.79 | GAA (0.47) | SMN1; SMN2ALDH1A1GAAPCSK9ADORA2B | |
| SCHEMBL28814905 | 0.78 | GAA (0.59) | SMN1; SMN2ALDH1A1GAAADORA2BRXFP1 | |
| SCHEMBL7434632 | 0.78 | GAA (0.48) | SMN1; SMN2ALDH1A1GAAPCSK9ADORA2B | |
| SCHEMBL7439781 | 0.77 | GAA (0.60) | SMN1; SMN2ALDH1A1GAAADORA2BRXFP1 | |
| SCHEMBL4264289 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1PCSK9ADORA2BRXFP1 | |
| SCHEMBL7441118 | 0.75 | GAA (0.47) | SMN1; SMN2ALDH1A1GAAADORA2BRXFP1 | |
| SCHEMBL7441123 | 0.75 | GAA (0.47) | SMN1; SMN2ALDH1A1GAAADORA2BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |