SCHEMBL7440136

SCHEMBL7440136

FCC(Cl)Sc1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.37
ALDH1A1 P00352 2/20 0.37
SMN1; SMN2 Q16637 4/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
MGLL Q99685 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TSHR P16473 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
PKM P14618 1/20 0.33
L3MBTL1 Q9Y468 2/20 0.32
POLB P06746 1/20 0.32
LMNA P02545 2/20 0.32
CHRNA7 P36544 1/20 0.32
FFAR1 O14842 1/20 0.31
GAA P10253 2/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9690804 0.77 MAPK1 (0.37) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL3688482 0.77 ALDH1A1 (0.40) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL3696001 0.74 SMN1; SMN2 (0.38) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL638508 0.74 MAOA (0.39) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL10936991 0.73 SMN1; SMN2 (0.41) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL585722 0.73 MAOA (0.42) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL12162316 0.72 MAPK1 (0.38) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL3911663 0.72 SMN1; SMN2 (0.45) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL14894782 0.70 SMN1; SMN2 (0.43) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL11403383 0.70 SMN1; SMN2 (0.38) MAPK1ALDH1A1SMN1; SMN2MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0739338-B1 SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE UNIV WICHITA STATE (US) 2002-04-10 EP disclosed
EP-0739338-A4 NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE UNIV WICHITA STATE (US) 1997-03-26 EP disclosed
EP-0739338-A1 NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE THE WICHITA STATE UNIVERSITY (US) 1996-10-30 EP disclosed
US-5550139-A ANTIINFLAMMATORY AGENT, ANTITUMOR AGENT, ANTICARCINOGENIC AGENT THE WICHITA STATE UNIVERSITY (US) 1996-08-27 US disclosed
WO-1995018797-A1 NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE THE WICHITA STATE UNIVERSITY (US) 1995-07-13 WO disclosed