Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 6/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 8/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 7/20 | 0.37 |
| ▸ | CASP7 | P55210 | 6/20 | 0.37 |
| ▸ | HRH1 | P35367 | 5/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429909 | 0.92 | CASP1 (0.48) | CASP1CASP3CASP8CASP7HRH1 | |
| SCHEMBL7432245 | 0.89 | CASP1 (0.42) | CASP1RENCASP3CASP8CASP7 | |
| SCHEMBL7435774 | 0.87 | CASP1 (0.41) | CASP1RENCCKBRBACE1 | |
| SCHEMBL7429733 | 0.86 | CASP1 (0.42) | CASP1RENCASP3CASP8CASP7 | |
| SCHEMBL7427145 | 0.83 | CASP1 (0.49) | CASP1CASP3CASP8CASP7HRH1 | |
| SCHEMBL7431671 | 0.82 | CASP1 (0.49) | CASP1CASP3CASP8CASP7HRH1 | |
| SCHEMBL7441956 | 0.82 | CASP1 (0.48) | CASP1CASP3CASP8CASP7HRH1 | |
| SCHEMBL7432271 | 0.81 | CASP1 (0.51) | CASP1CASP3CASP8CASP7HRH1 | |
| SCHEMBL7441949 | 0.80 | CASP3 (0.42) | CASP1CASP3 | |
| SCHEMBL7437728 | 0.79 | CASP1 (0.49) | CASP1CASP3CASP8CASP7HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |