Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.53 |
| ▸ | F10 | P00742 | 4/20 | 0.51 |
| ▸ | PLG | P00747 | 3/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851934 | 0.86 | F2 (0.50) | F2PRSS1F10PLGPLAT | |
| SCHEMBL9223678 | 0.85 | F10 (0.51) | F2F10PLGPLAU | |
| SCHEMBL8159130 | 0.82 | PLG (0.66) | F2F10PLGPLAU | |
| SCHEMBL7370483 | 0.82 | F2 (0.47) | F2PRSS1F10PLGPLAT | |
| SCHEMBL9189122 | 0.77 | PLG (0.67) | F2PRSS1F10PLGPLAU | |
| SCHEMBL29514928 | 0.77 | PLG (0.67) | F2PRSS1F10PLGPLAU | |
| SCHEMBL872422 | 0.77 | PLG (0.67) | F2PRSS1F10PLGPLAU | |
| SCHEMBL29651383 | 0.77 | PLG (0.67) | F2PRSS1F10PLGPLAU | |
| SCHEMBL8144360 | 0.77 | PLG (0.67) | F2PRSS1F10PLGPLAU | |
| SCHEMBL6790382 | 0.77 | F2 (0.56) | F2F10PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367713-B2 | Antidote for blood anticoagulants based on factor VIII | CIBA GEIGY AG (CH) | 1995-01-04 | — | — | EP | claimed |
| EP-0367713-A1 | Antidote for blood anticoagulants based on factor VIII | CIBA-GEIGY AG (CH) | 1990-05-09 | — | — | EP | claimed |
| EP-0722449-A1 | BOROPEPTIDE INHIBITORS OF THROMBIN WHICH CONTAIN A SUBSTITUTED PYRROLIDINE RING | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| WO-1995009859-A1 | BOROPEPTIDE INHIBITORS OF THROMBIN WHICH CONTAIN A SUBSTITUTED PYRROLIDINE RING | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |
| EP-0367713-B2 | Antidote for blood anticoagulants based on factor VIII | CIBA GEIGY AG (CH) | 1995-01-04 | — | — | EP | disclosed |
| EP-0367713-A1 | Antidote for blood anticoagulants based on factor VIII | CIBA-GEIGY AG (CH) | 1990-05-09 | — | — | EP | disclosed |