Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6798820 | 0.83 | CYSLTR2 (0.53) | PDE10ACYSLTR1CYSLTR2CYP1A2 | |
| SCHEMBL2334595 | 0.81 | CYSLTR2 (0.52) | PDE10ACYSLTR1CYSLTR2CYP1A2 | |
| SCHEMBL538491 | 0.80 | GPBAR1 (0.54) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL13017040 | 0.80 | PDE10A (0.46) | PDE10ACYSLTR1CYSLTR2GPBAR1ALDH1A1 | |
| SCHEMBL2913941 | 0.79 | PDE10A (0.61) | PDE10ACYSLTR1CYSLTR2CYP1A2 | |
| SCHEMBL27539069 | 0.79 | PDE10A (0.44) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL13017043 | 0.79 | PDE10A (0.44) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL860157 | 0.79 | KCNH2 (0.58) | PDE10ACYSLTR1CYSLTR2GPBAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27600363 | 0.79 | GPBAR1 (0.52) | PDE10ACYSLTR1CYSLTR2GPBAR1ALDH1A1 | |
| Bromide SCHEMBL27600369 | 0.79 | GPBAR1 (0.52) | PDE10ACYSLTR1CYSLTR2GPBAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | ANGIOGENEX | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | BRAF, MAPK1, RAF1 | PDE10A 2419/4885CYSLTR1 2259/4885CYSLTR2 2460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.