Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.41 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CBFB | Q13951 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8787255 | 0.83 | SMN1; SMN2 (0.56) | CYP2A6POLBSMN1; SMN2TP53RXFP1 | |
| SCHEMBL8786755 | 0.81 | CYP4F2 (0.60) | CYP2A6POLBSMN1; SMN2TP53RXFP1 | |
| SCHEMBL5319440 | 0.77 | CYP2A6 (0.64) | CYP2A6POLBSMN1; SMN2TP53RXFP1 | |
| SCHEMBL6616239 | 0.74 | CYP1A2 (0.52) | SMN1; SMN2ALDH1A1HPGDHSD17B10CYP4F2 | |
| SCHEMBL7011991 | 0.73 | OPRD1 (0.51) | CYP2A6POLBSMN1; SMN2TP53RXFP1 | |
| SCHEMBL4902378 | 0.73 | OPRD1 (0.51) | CYP2A6POLBSMN1; SMN2TP53RXFP1 | |
| SCHEMBL11809718 | 0.73 | NLRP3 (0.46) | SMN1; SMN2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5161089 | 0.72 | HDAC3 (0.51) | POLBSMN1; SMN2TP53RXFP1ALDH1A1 | |
| SCHEMBL6991501 | 0.72 | CYP2A6 (0.62) | CYP2A6POLBSMN1; SMN2TP53RXFP1 | |
| Hydrochloric Acid SCHEMBL7008761 | 0.72 | OPRD1 (0.50) | CYP2A6POLBSMN1; SMN2TP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207677-B1 | ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA | H. LUNDBECK A/S (DK) | 2001-03-27 | — | — | US | disclosed |
| US-6031099-A | Piperidine derivates having anxiolytic effect | H. LUNDBECK A/S (DK) | 2000-02-29 | — | — | US | disclosed |
| EP-0593511-B1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | LUNDBECK & CO AS H (DK) | 1998-09-02 | — | — | EP | disclosed |
| EP-0859004-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| EP-0853085-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-07-15 | — | — | EP | disclosed |
| US-5665725-A | Piperidine derivatives having anxiolytic effect | Lundbeck, H. (DK) | 1997-09-09 | — | — | US | disclosed |
| EP-0593511-A1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | H. LUNDBECK A/S (DK) | 1994-04-27 | — | — | EP | disclosed |
| WO-1992022554-A1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | H. LUNDBECK A/S (DK) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518805-A1 | Piperidine derivatives | H. LUNDBECK A/S (DK) | 1992-12-16 | — | — | EP | disclosed |