Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.63 |
| ▸ | PDE4A | P27815 | 10/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371531 | 0.84 | PDE4D (0.69) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL131830 | 0.83 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3371565 | 0.82 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7913459 | 0.82 | PDE4D (0.70) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL29620831 | 0.79 | TSHR (0.63) | PDE4BPDE4D | |
| SCHEMBL426444 | 0.79 | TSHR (0.63) | PDE4BPDE4D | |
| SCHEMBL4825206 | 0.78 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7366699 | 0.77 | PDE4B (0.62) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL9184286 | 0.77 | PDE4B (0.62) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7359869 | 0.76 | MAPT (0.67) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998008844-A1 | THIAZOLE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE-IV | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-03-05 | — | — | WO | disclosed |