Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.70 |
| ▸ | PDE4A | P27815 | 7/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371531 | 0.86 | PDE4D (0.69) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL4162765 | 0.85 | PDE5A (0.70) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7441489 | 0.82 | PDE4B (0.63) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1333620 | 0.81 | CYP1A2 (0.81) | CYP1A2CYP2C19CYP2D6HPGDCYP3A4 | |
| SCHEMBL4825206 | 0.80 | PDE4B (0.61) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7366699 | 0.79 | PDE4B (0.62) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL9184286 | 0.79 | PDE4B (0.62) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7359869 | 0.78 | MAPT (0.67) | PDE4DPDE4APDE4BPDE4CHPGD | |
| SCHEMBL27472680 | 0.77 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4CCYP1A2 | |
| SCHEMBL3371565 | 0.77 | PDE4B (0.57) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |