Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 7/20 | 0.39 |
| ▸ | CASP3 | P42574 | 7/20 | 0.39 |
| ▸ | CASP7 | P55210 | 7/20 | 0.39 |
| ▸ | CASP6 | P55212 | 7/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 7/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441563 | 1.00 | POLB (0.40) | POLBALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7312203 | 0.94 | ALDH1A1 (0.38) | POLBALDH1A1HPGDRAB9ACASP1 | |
| SCHEMBL7312214 | 0.94 | ALDH1A1 (0.38) | POLBALDH1A1HPGDRAB9ACASP1 | |
| SCHEMBL7301044 | 0.93 | HPGD (0.49) | POLBALDH1A1HPGDRAB9ACASP1 | |
| SCHEMBL7301037 | 0.93 | HPGD (0.49) | POLBALDH1A1HPGDRAB9ACASP1 | |
| SCHEMBL7431376 | 0.92 | HPGD (0.41) | POLBALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7431388 | 0.92 | HPGD (0.41) | POLBALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL7436020 | 0.92 | HPGD (0.46) | POLBALDH1A1HPGDRAB9ACASP1 | |
| SCHEMBL7436014 | 0.92 | HPGD (0.46) | POLBALDH1A1HPGDRAB9ACASP1 | |
| SCHEMBL7435041 | 0.91 | LMNA (0.39) | POLBALDH1A1HPGDCASP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |