Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.79 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.79 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.71 |
| ▸ | F13A1 | P00488 | 1/20 | 0.71 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441298 | 1.00 | HDAC3 (0.79) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7436977 | 1.00 | HDAC3 (0.79) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7280705 | 0.98 | HDAC3 (0.77) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7440269 | 0.95 | LMNA (0.82) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL23230151 | 0.90 | LMNA (0.91) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL9644621 | 0.90 | LMNA (0.91) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL14952381 | 0.90 | LMNA (0.85) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL14302230 | 0.90 | LMNA (0.85) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL8356049 | 0.90 | LMNA (0.85) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL17117356 | 0.90 | HDAC1 (0.79) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4939147-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC. (GB) | 1990-07-03 | — | — | US | disclosed |
| US-4922022-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| EP-0314725-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS plc (GB) | 1989-05-10 | — | — | EP | disclosed |
| WO-1988009326-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS PLC (GB) | 1988-12-01 | — | — | WO | disclosed |
| EP-0292202-A1 | 2-(3,4-Dihydroxyphenyl ethyl amines, their preparation and use as pharmaceutical compounds | FISONS plc (GB) | 1988-11-23 | — | — | EP | disclosed |