Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.77 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.77 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.77 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.73 |
| ▸ | F13A1 | P00488 | 1/20 | 0.68 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441298 | 0.98 | HDAC3 (0.79) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7441870 | 0.98 | HDAC3 (0.79) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7436977 | 0.98 | HDAC3 (0.79) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL7440269 | 0.97 | LMNA (0.82) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL8356049 | 0.92 | LMNA (0.85) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL17117356 | 0.91 | HDAC1 (0.79) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL4074353 | 0.91 | HDAC3 (0.87) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL8357788 | 0.90 | LMNA (0.88) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL166980 | 0.89 | L3MBTL1 (0.71) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL13073412 | 0.89 | HDAC3 (0.78) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223598-B1 | CATECHOLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | FISONS plc (GB) | 1991-06-12 | — | — | EP | disclosed |
| US-5013760-A | Phenylethylamine derivatives and pharmaceutical use | FISONS PLC (GB) | 1991-05-07 | — | — | US | disclosed |
| US-4939147-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC. (GB) | 1990-07-03 | — | — | US | disclosed |
| EP-0375668-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1990-06-27 | — | — | EP | disclosed |
| US-4922022-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| US-4912222-A | Antihistamines related to cyproheptadine | FISONS CORPORATION (US) | 1990-03-27 | — | — | US | disclosed |
| WO-1989012443-A1 | NOVEL DIBENZO-CYCLOHEPTENYL, -CYCLOHEPTYL AND -OXEPINYL AMINES HAVING ANTIHISTAMINIC PROPERTIES | FISONS CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347123-A2 | Dibenzo-cycloheptenyl, -cycloheptyl and -oxepinyl amines having antihistaminic properties | FISONS CORPORATION (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4885313-A | 3,4-Dihydroxyphenylethylamine derivatives and their use | FISONS PLC (GB) | 1989-12-05 | — | — | US | disclosed |
| US-4883804-A | Aromatic compounds | FISONS PLC (GB) | 1989-11-28 | — | — | US | disclosed |
| US-4868306-A | Compounds | FISONS PLC (GB) | 1989-09-19 | — | — | US | disclosed |
| US-4803225-A | Dihydroxy-phenethylamino compounds useful as pharmaceuticals | FISONS, PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| US-4791216-A | Para ethyl amino phenol pharmaceutical compounds | FISONS PLC (GB) | 1988-12-13 | — | — | US | disclosed |
| US-4720586-A | Substituted 3,4-dihydroxy-phenylethylamino compounds | FISONS, PLC (GB) | 1988-01-19 | — | — | US | disclosed |
| EP-0223598-A2 | Catecholamine derivatives, processes for their preparation and pharmaceutical compositions thereof | FISONS plc (GB) | 1987-05-27 | — | — | EP | disclosed |
| US-4657929-A | Compounds | FISONS PLC (GB) | 1987-04-14 | — | — | US | disclosed |
| EP-0142283-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1985-05-22 | — | — | EP | disclosed |
| EP-0072061-A1 | Amine derivatives, processes for their production and pharmaceutical compositions containing them | FISONS plc (GB) | 1983-02-16 | — | — | EP | disclosed |