Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.86 |
| ▸ | DRD3 | P35462 | 10/20 | 0.64 |
| ▸ | DRD2 | P14416 | 9/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8189463 | 0.96 | HTR1A (0.79) | HTR1ADRD3DRD2HRH4ADRA1A | |
| Hydrochloric Acid SCHEMBL8183104 | 0.84 | HTR1A (0.62) | HTR1ADRD3DRD2HRH4ADRA1A | |
| Hydrochloric Acid SCHEMBL7920306 | 0.82 | DRD2 (0.62) | HTR1ADRD3DRD2DRD4 | |
| SCHEMBL7381044 | 0.81 | DRD3 (0.67) | HTR1ADRD3DRD2HRH4ADRA1A | |
| SCHEMBL14720483 | 0.80 | HRH4 (0.74) | DRD3DRD2HRH4ADRA1ADRD4 | |
| SCHEMBL10724572 | 0.79 | DRD3 (0.78) | HTR1ADRD3DRD2ADRA1ADRD4 | |
| SCHEMBL7290257 | 0.79 | HTR1A (0.56) | HTR1ADRD3DRD2DRD4 | |
| SCHEMBL7392912 | 0.79 | DRD3 (0.73) | HTR1ADRD3DRD2HRH4ADRA1A | |
| SCHEMBL7287704 | 0.79 | HTR1A (0.54) | HTR1ADRD3DRD2 | |
| SCHEMBL7432969 | 0.78 | DRD3 (1.00) | HTR1ADRD3DRD2ADRA1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779284-B1 | Novel 2-naphthamide derivatives and their use in therapy as D3 receptor agonists | INST NAT SANTE RECH MED (FR) | 2002-07-10 | — | — | EP | claimed |
| US-5985895-A | 2-naphthamide derivatives and their therapeutic applications | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-INSERM (FR) | 1999-11-16 | — | — | US | claimed |
| US-5985895-A | 2-naphthamide derivatives and their therapeutic applications | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-INSERM (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5872119-A | 2-Naphthamide derivatives and their therapeutic applications | Institut National De La Sante et De La Recherche Medicale--INSERM (FR) | 1999-02-16 | — | — | US | disclosed |