⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724401 | 1.00 | — | — | |
| SCHEMBL4955415 | 0.83 | GPR84 (0.43) | — | |
| SCHEMBL7446893 | 0.83 | GPR84 (0.43) | — | |
| SCHEMBL4953102 | 0.81 | TSHR (0.41) | — | |
| SCHEMBL7398943 | 0.80 | OR51E2 (0.40) | — | |
| SCHEMBL7398945 | 0.80 | OR51E2 (0.40) | — | |
| SCHEMBL4956102 | 0.80 | GPR84 (0.50) | — | |
| SCHEMBL7377715 | 0.78 | GPR84 (0.53) | — | |
| SCHEMBL721067 | 0.78 | — | — | |
| SCHEMBL1405991 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | disclosed |