Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.49 |
| ▸ | TOP1 | P11387 | 2/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436085 | 0.92 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7444931 | 0.89 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7436598 | 0.86 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7437304 | 0.80 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7438319 | 0.79 | CCR1 (0.47) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7445176 | 0.78 | CCR1 (0.41) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL3712064 | 0.78 | KDM4E (0.43) | PDE4APDE4BPDE4CPDE4DCCR1 | |
| SCHEMBL7437896 | 0.76 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7434938 | 0.76 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7445385 | 0.74 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |