Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.54 |
| ▸ | CDK2 | P24941 | 9/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435614 | 0.91 | GSK3B (0.42) | GSK3BCDK2CCNE1 | |
| SCHEMBL7439041 | 0.88 | CDK2 (0.43) | GSK3BCDK2 | |
| SCHEMBL7438645 | 0.87 | GSK3B (0.39) | GSK3BCDK2CCNE1 | |
| SCHEMBL7440140 | 0.85 | PRKAB2 (0.48) | GSK3BCDK2CCNE1 | |
| SCHEMBL7442658 | 0.82 | GSK3B (0.56) | GSK3BCDK2CCNE1 | |
| SCHEMBL7442971 | 0.81 | GSK3B (0.35) | GSK3B | |
| SCHEMBL7435233 | 0.81 | GSK3B (0.31) | GSK3B | |
| SCHEMBL7437917 | 0.80 | AGTR1 (0.32) | GSK3B | |
| SCHEMBL7440104 | 0.80 | KMT2A (0.43) | GSK3BCDK2 | |
| SCHEMBL7440210 | 0.76 | AGTR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |