Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445594 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2ADORA2BRXFP1ALDH1A1PCSK9 | |
| SCHEMBL4263443 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2ADORA2BRXFP1ALDH1A1POLB | |
| SCHEMBL7443156 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2ADORA2BRXFP1ALDH1A1PCSK9 | |
| SCHEMBL7110383 | 0.71 | SMN1; SMN2 (0.54) | SMN1; SMN2ADORA2BRXFP1ALDH1A1POLB | |
| SCHEMBL1944405 | 0.71 | ADORA2B (1.00) | SMN1; SMN2ADORA2BRXFP1ALDH1A1POLB | |
| SCHEMBL555404 | 0.70 | PDE1A (0.73) | SMN1; SMN2ADORA2BRXFP1ALDH1A1POLB | |
| SCHEMBL8179399 | 0.70 | SMN1; SMN2 (0.49) | SMN1; SMN2ADORA2BRXFP1ALDH1A1POLB | |
| SCHEMBL12604460 | 0.70 | PCSK9 (1.00) | SMN1; SMN2ALDH1A1PCSK9MEN1KMT2A | |
| SCHEMBL20011033 | 0.69 | SMN1; SMN2 (0.76) | SMN1; SMN2ADORA2BRXFP1ALDH1A1POLB | |
| SCHEMBL9586511 | 0.69 | PCSK9 (0.51) | SMN1; SMN2ALDH1A1PCSK9POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |