Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436778 | 0.88 | L3MBTL1 (0.48) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL7446018 | 0.84 | L3MBTL1 (0.49) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL7436417 | 0.80 | L3MBTL1 (0.46) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL22004727 | 0.78 | L3MBTL1 (0.53) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL7434514 | 0.76 | GAA (0.47) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL24992399 | 0.73 | KMT2A (0.61) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL17925766 | 0.73 | GAA (0.51) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL19838819 | 0.72 | RIPK1 (0.55) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL13201415 | 0.72 | KMT2A (0.55) | L3MBTL1KMT2AMEN1DDB1CRBN | |
| SCHEMBL28760989 | 0.72 | HPGD (0.50) | L3MBTL1KMT2AMEN1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066666-A | OPTIONALLY N-SUBSTITUTED 3-MONO- AND DI-SUBSTITUTED 2-PYRROLIDINONES AND THIOLACTAM ANALOGS; TREAT SEIZURES, ANXIETY, AND ENHANCING 4-AMINOBUTYRIC ACID (GABA)-INDUCED CHLORIDE CURRENTS AT GABA RECEPTOR/IONOPHORE COMPLEX | WASHINGTON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| US-5776959-A | Anticonvulsant and anxiolytic lactam and thiolactam derivatives | WASHINGTON UNIVERSITY (US) | 1998-07-07 | — | — | US | disclosed |