Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 12/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 12/20 | 0.41 |
| ▸ | USP1 | O94782 | 1/20 | 0.38 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9591953 | 0.72 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL7434010 | 0.72 | TSHR (0.51) | TSHRUSP2ALDH1A1ALOX15MAPK1 | |
| SCHEMBL9589454 | 0.71 | AGTR1 (0.64) | TSHRALDH1A1ALOX15MAPK1LMNA | |
| SCHEMBL7670834 | 0.70 | AGTR1 (0.39) | TSHRALDH1A1LMNAAGTR1AGTR2 | |
| SCHEMBL9589075 | 0.70 | AGTR1 (0.60) | AGTR1AGTR2USP1WDR48 | |
| SCHEMBL7436221 | 0.69 | AGTR1 (0.67) | LMNAAGTR1AGTR2 | |
| SCHEMBL7020979 | 0.69 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL7647188 | 0.68 | POLB (0.41) | TSHRALDH1A1MAPK1AGTR1AGTR2 | |
| SCHEMBL9590412 | 0.67 | AGTR1 (0.66) | TSHRALDH1A1ALOX15MAPK1LMNA | |
| SCHEMBL9591999 | 0.66 | AGTR1 (0.67) | TSHRALDH1A1ALOX15MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5466692-A | Substituted pyridopyrimidines and antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0618207-A1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-05 | — | — | EP | disclosed |