Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 7/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438948 | 0.79 | CA1 (0.45) | CA1CA2CA7RENCYP2D6 | |
| SCHEMBL7281729 | 0.76 | REN (0.56) | CA1CA2CA7RENCTSK | |
| SCHEMBL6490683 | 0.76 | CA1 (0.55) | CA1CA2CA7RENCYP2D6 | |
| SCHEMBL5170605 | 0.76 | CA1 (0.55) | CA1CA2CA7RENCYP2D6 | |
| SCHEMBL6487911 | 0.76 | CA1 (0.55) | CA1CA2CA7RENCYP2D6 | |
| SCHEMBL9833654 | 0.74 | REN (0.42) | RENCTSKCTSS | |
| SCHEMBL7364723 | 0.74 | CA1 (0.57) | CA1CA2CA7RENCYP2D6 | |
| SCHEMBL12018725 | 0.74 | CA1 (0.57) | CA1CA2CA7RENCYP2D6 | |
| SCHEMBL10982144 | 0.74 | CA1 (0.57) | CA1CA2CA7RENCYP2D6 | |
| SCHEMBL7266599 | 0.74 | REN (0.58) | RENCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| US-4645759-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0172347-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |