Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442169 | 0.91 | CASP3 (0.44) | CASP3CASP1 | |
| SCHEMBL7441581 | 0.89 | CASP1 (0.40) | KLK7KLK5SYKMAPTCASP3 | |
| SCHEMBL7439592 | 0.87 | CASP1 (0.39) | KLK7KLK5SYKMAPTCASP3 | |
| SCHEMBL7443609 | 0.86 | CASP1 (0.42) | KLK7KLK5SYKMAPTCASP1 | |
| SCHEMBL7432756 | 0.86 | CYP1A2 (0.41) | KLK7KLK5SYKMAPTXBP1 | |
| SCHEMBL7435672 | 0.84 | ATM (0.44) | KLK7KLK5SYKMAPTCASP1 | |
| SCHEMBL7441638 | 0.83 | CASP1 (0.46) | KLK7KLK5SYKCASP1 | |
| SCHEMBL7433669 | 0.82 | ATM (0.43) | KLK7KLK5SYKMAPTCASP1 | |
| SCHEMBL7436188 | 0.81 | CASP1 (0.39) | KLK7KLK5SYKMAPTCASP1 | |
| SCHEMBL7438347 | 0.80 | CASP1 (0.41) | KLK7KLK5SYKMAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |