Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 3/20 | 0.42 |
| ▸ | FNTB | P49356 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.31 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444148 | 1.00 | FNTA (0.42) | FNTAFNTBTHRBPGGT1BFAAH | |
| SCHEMBL7440851 | 0.85 | GRIK1 (0.34) | FNTAFNTBTHRBPGGT1BGRIK1 | |
| SCHEMBL7440860 | 0.85 | GRIK1 (0.34) | FNTAFNTBTHRBPGGT1BGRIK1 | |
| SCHEMBL8325846 | 0.78 | FNTA (0.55) | FNTAFNTBTHRBPGGT1B | |
| SCHEMBL8325853 | 0.78 | FNTA (0.55) | FNTAFNTBTHRBPGGT1B | |
| Chloromethane SCHEMBL10608041 | 0.74 | FNTA (0.41) | FNTAFNTBTHRBPGGT1BGRIK1 | |
| SCHEMBL12490349 | 0.73 | HDAC3 (0.43) | FNTAFNTBTHRBPGGT1BGRIK1 | |
| SCHEMBL7266900 | 0.73 | GRIK1 (0.35) | FNTAFNTBTHRBPGGT1BGRIK1 | |
| SCHEMBL7266902 | 0.73 | GRIK1 (0.35) | FNTAFNTBTHRBPGGT1BGRIK1 | |
| SCHEMBL3133846 | 0.73 | HDAC3 (0.43) | FNTAFNTBTHRBPGGT1BGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580871-A | FOR TREATMENT OF CONGESTIVE HEART FAILURE | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-03 | — | — | US | disclosed |
| US-5432188-A | Treating congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5166147-A | Congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |