Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31453955 | 0.71 | SLC22A12 (0.38) | SLC22A12MAPTKDM4EPOLBHCAR2 | |
| SCHEMBL2732538 | 0.69 | CYP1A2 (0.39) | SLC22A12MAPTKDM4EPOLBHCAR2 | |
| SCHEMBL15463768 | 0.69 | POLB (0.38) | SLC22A12ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL749433 | 0.68 | CYP11B2 (0.46) | SLC22A12 | |
| SCHEMBL24534060 | 0.66 | CYP11B1 (0.42) | SLC22A12MAPTKDM4EPOLBHCAR2 | |
| SCHEMBL746198 | 0.66 | POLB (0.41) | POLBHCAR2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3507833 | 0.66 | CYP11B1 (0.42) | SLC22A12MAPTKDM4EPOLBHCAR2 | |
| SCHEMBL13724593 | 0.66 | POLB (0.37) | SLC22A12MEN1KMT2AMAPTKDM4E | |
| SCHEMBL3476604 | 0.66 | KDM4E (0.38) | SLC22A12MEN1LMNAGAAKMT2A | |
| SCHEMBL31226639 | 0.65 | KDM4E (0.40) | LMNAMAPTKDM4EPOLBHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429995-A1 | ARYL PYRIDINE AS ALDOSTERONE SYNTHASE INHIBITORS | Novartis AG (CH) | 2012-03-21 | — | — | EP | disclosed |