Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 15/20 | 0.50 |
| ▸ | DRD2 | P14416 | 14/20 | 0.50 |
| ▸ | DRD3 | P35462 | 12/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1282727 | 0.87 | DRD4 (0.47) | DRD4DRD2DRD3HTR1BGAA | |
| SCHEMBL5316000 | 0.82 | KMT2A (0.53) | DRD4DRD2DRD3HTR1BTSHR | |
| SCHEMBL2181408 | 0.82 | DRD2 (0.44) | DRD4DRD2DRD3 | |
| SCHEMBL2182360 | 0.81 | SMN1; SMN2 (0.53) | DRD4DRD2DRD3HTR1BGAA | |
| SCHEMBL7917299 | 0.81 | DRD4 (0.74) | DRD4DRD2DRD3HTR1BGAA | |
| SCHEMBL2184548 | 0.81 | DRD2 (0.46) | DRD4DRD2DRD3GAAKDM4E | |
| SCHEMBL127508 | 0.80 | LTA4H (0.50) | KDM4E | |
| SCHEMBL7019049 | 0.80 | DRD4 (0.47) | DRD4DRD2DRD3HTR1BGAA | |
| SCHEMBL14294277 | 0.79 | DRD2 (0.79) | DRD4DRD2DRD3KDM4E | |
| SCHEMBL4227450 | 0.79 | HTR1B (0.64) | DRD4DRD2DRD3HTR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541151-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |