Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 8/20 | 0.57 |
| ▸ | PDE4A | P27815 | 10/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.51 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443615 | 0.82 | PDE4A (0.70) | CYP2C9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7445534 | 0.80 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL4025246 | 0.80 | CYP2C9 (0.48) | CYP2C9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7446644 | 0.79 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL6219266 | 0.78 | CYP2C9 (0.65) | CYP2C9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6219992 | 0.77 | CYP2C9 (0.52) | CYP2C9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7439316 | 0.77 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7445586 | 0.76 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7450047 | 0.75 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL14565377 | 0.75 | PDE4A (0.52) | CYP2C9PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |