Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.50 |
| ▸ | TOP1 | P11387 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443505 | 0.85 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7445534 | 0.84 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7444411 | 0.79 | CYP2C9 (0.57) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7439316 | 0.78 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7444371 | 0.78 | KDM4E (0.43) | KDM4EMEN1PSMD14ALDH1A1LMNA | |
| SCHEMBL7445586 | 0.77 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL14565377 | 0.76 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7450047 | 0.76 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7440672 | 0.75 | CCR1 (0.57) | PDE4APDE4BPDE4CPDE4DTOP1 | |
| SCHEMBL7436598 | 0.72 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |